Danny Hope (2009-12) was the one that really magnifies the Purdue-OSU factor. They played each other all four years that Hope coached the Boilers. He had two wins and a close loss (7pts) vs only one blowout loss (vacated). But he didn't do very well against the rest of the league, being shown the door after just 4 years. He had Hoke syndrome, where he could really get his guys up for OSU but struggled otherwise.
Now you take that out of there, and Purdue is still no slouch against OSU, 3-6 with each of the three wins at the expense of a different OSU HoF HC; John Cooper (2000), Jim Tressel (2004) and Urban Meyer (2018). So it wasn't ALL Hope. But a lot if it was Hope. The Tiller ones in 2000 and 04 are not all that alarming, Purdue won the Big Ten in 2000 with Drew Brees for example, while John Cooper was putting together a season that would get himself fired.